My research interests are in dynamical systems theory and control, with applications to the fields of systems biology and synthetic biology. Most recently, I:
- pioneered a control-oriented dynamical systems approach to modeling trauma coagulation to help tailor the resuscitation of severely injured patients;
- quantified why biomanufacturing technologies are more useful for space exploration than traditional chemical and mechanical techniques; and
- showed mathematically that a possible rationale for natural evolution is optimally-efficient search in a dynamic environment, a process that is tunably responsive to environment variations through the amount of selection and that is also translatable to non-biological applications that similarly operate in variable environs.
Systems BiologyTargeted Clinical Control of Trauma Patient Coagulation
This research develops a methodology for personalizing the clinical treatment of severely injured patients with trauma-induced coagulation deficits.
This work models biological performance in fluctuating environments, and deploys a resultant, biologically inspired, on-line, search-based optimization technique called Selective Evolutionary Generation Systems (SEGS) in several applications.
- Amor A. Menezes and Pierre T. Kabamba. Efficient search and responsiveness trade-offs in a Markov chain model of evolution in dynamic environments. Mathematical Biosciences, 276:44-58, June 2016.
- Amor A. Menezes and Pierre T. Kabamba. Efficient and resilient micro air vehicle flapping wing gait evolution for hover and trajectory control. Engineering Applications of Artificial Intelligence, 54:1-16, September 2016.
- Amor A. Menezes, Dhaval D. Shah and Ilya V. Kolmanovsky. An evaluation of stochastic model-dependent and model-independent glider flight management. In press, IEEE Transactions on Control Systems Technology.
This effort seeks to identify a generalized set of biological signal processing modules for use in synthetic biology applications.
Techniques from synthetic biology promise to be a useful approach to payload minimization for long-duration space missions.
- Amor A. Menezes, John Cumbers, John A. Hogan, and Adam P. Arkin. Towards synthetic biological approaches to resource utilization on space missions. Journal of the Royal Society Interface, 12(102):20140715, January 6, 2015. Cover article.
- Amor A. Menezes, Michael G. Montague, John Cumbers, John A. Hogan, and Adam P. Arkin. Grand challenges in space synthetic biology. Journal of the Royal Society Interface, 12(113):20150803, December 6, 2015. Headline review article in synthetic biology.